Summary

I.       The adaptive immune system: B cells, T cells- diverse, self-tolerant, and specific   

II.      Thymic Selection: positive and negative selection, specificity from weak amino-acids, extreme value distribution

[Quorum sensing for peripheral tolerance]                                            

III.     Affinity Maturation: Evolution in the Germinal Center                             

dependence of potency on spike density   

the puzzle of low HIV spike density              

synthetic nano-particle vaccination                       

[Broadly neutralizing Antibodies: Sequential versus cocktail administration of antigen variants]

vs.

IV.    Mutations of virus in a host: Mean-field dynamics on a fitness landscape

University of Colorado                      James Franck Institute Seminar               5 November 2019

Diversity, tolerance, and maturation of the adaptive immune response

Andrej Kosmrlj,     Hanrong Chen,       Assaf Amitai,         Shenshen Wang

Tom Butler, John Barton, A. Jha, E. Shakhnovich, E. Huseby

Arup K. Chakraborty 

Next (Adaptive immunity) Outline Adaptive Immunity Thymic Selection Quorum sensing Affinity Maturation Broadly neutralizing Abs EMF dynamics Summary