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Renato Umeton, Ph.D.

Data Science, Machine Learning, Optimization, Biostatistics.

 

PublicationsYear
Use of targeted next generation sequencing to characterize tumor mutational burden and efficacy of immune checkpoint inhibition in small cell lung cancer
B Ricciuti, S Kravets, SE Dahlberg, R Umeton, A Albayrak, SJ Subegdjo, ...
Journal for ImmunoTherapy of Cancer 7 (1), 87, 2019
2019
Mutational analysis of 472 urothelial carcinoma across grades and anatomic sites
AH Nassar, R Umeton, J Kim, K Lundgren, L Harshman, EM Van Allen, ...
Clinical Cancer Research 25 (8), 2458-2470, 2019
12019
PTEN alterations and tumor mutational burden as potential predictors of resistance or response to immune checkpoint inhibitors in metastatic triple-negative breast cancer
R Barroso-Sousa, S Tyekucheva, S Pernas-Simon, P Exman, E Jain, ...
Cancer Research 79 (4 Supplement), P5-12-02-P5-12-02, 2019
2019
Significant enrichment of Herpesvirus interactors in GWAS data suggests causal inferences for the association between Epstein Barr virus and multiple sclerosis
R Mechelli, R Umeton, S Srinivasan, A Fornasiero, M Ferraldeschi, ...
bioRxiv, 624049, 2019
2019
Machine Learning, Optimization, and Data Science (4th International Conference, LOD 2018, Volterra, Italy, September 13-16, 2018, Revised Selected Papers)
G Nicosia, P Pardalos, G Giuffrida, R Umeton, V Sciacca
Book - Springer 11331, 1-584, 2019
2019
Genome-Wide Multiple Sclerosis Association Data and Coagulation
S La Starza, M Ferraldeschi, MC Buscarinu, S Romano, A Fornasiero, ...
Frontiers in Neurology 10, 95, 2019
12019
Machine Learning, Optimization, and Big Data (Third International Conference, MOD 2017, Volterra, Italy, September 14–17, 2017, Revised Selected Papers)
G Nicosia, P Pardalos, G Giuffrida, R Umeton
Book - Springer 10710, 1-621, 2018
12018
Use of Tumor-Only Next Generation Sequencing to Identify Clinicopathologic and Genomic Correlates of Tumor Mutational Burden and Immunotherapy Response in Non-Small Cell Lung …
M Awad, NR Mahadevan, A Polio, EJ Aguilar, NI Vokes, B Ricciuti, ...
2018
Efficacy and Genomic Correlates of Response to Anti-PD1/PD-L1 Blockade in Non-Small Cell Lung Cancers Harboring Targetable Oncogenes
N Vokes, EJ Alguilar, A Adeni, R Umeton, L Sholl, H Rizvi, M Hellmann, ...
Journal of Thoracic Oncology 13 (10), S422, 2018
12018
PD-L1 Expression, Tumor Mutational Burden, and Response to Immunotherapy in Patients with MET exon 14 Altered Lung Cancers
JK Sabari, GC Leonardi, CA Shu, R Umeton, J Montecalvo, A Ni, R Chen, ...
Annals of Oncology, 2018
42018
Comprehensive genomic characterization of urothelial carcinomas
A Nassar, R Umeton, K Lundgren, LC Harshman, EM Van Allen, ...
Journal of Clinical Oncology 36 (15), 4527, 2018
2018
Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade
IF Dunn, Z Du, M Touat, MB Sisti, PY Wen, R Umeton, AM Dubuc, ...
JCO precision oncology 2018, 2018
12018
Fractal analysis of retinal vascular morphology in multiple sclerosis
M Cavallari, D Kimbrough, C Stamile, R Umeton, T Chitnis, C Guttmann
MULTIPLE SCLEROSIS JOURNAL 24, 370-371, 2018
2018
Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients
V Annibali, R Umeton, A Palermo, M Severa, MP Etna, S Giglio, ...
Journal of neuroimmunology 324, 165-171, 2018
12018
Intestinal Permeability in Relapsing-Remitting Multiple Sclerosis
MC Buscarinu, S Romano, R Mechelli, RP Umeton, M Ferraldeschi, ...
Neurotherapeutics, 1-7, 2018
102018
Somatic mutations in CDH1 and CTNNB1 in primary carcinomas at 13 anatomic sites
EL Busch, JL Hornick, R Umeton, A Albayrak, NI Lindeman, ...
Oncotarget 8 (49), 85680, 2017
22017
Different environmental stimuli may activate common biological processes potentially involved in multiple sclerosis
R Mechelli, R Umeton, R Renie, G Ristori, M Salvetti
MULTIPLE SCLEROSIS JOURNAL 23, 210, 2017
2017
The gut microbiome in active and stable relapsing multiple sclerosis
E Eleftheriou, RP Umeton, R Umeton, S Nedelcu, AL Contreras, L Hall, ...
MULTIPLE SCLEROSIS JOURNAL 23, 518, 2017
2017
A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials
C Eleuteri, S Olla, C Veroni, R Umeton, R Mechelli, S Romano, ...
Nature Scientific Reports 7 (www.nature.com/articles/srep45780), 45780, 2017
62017
Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study
MC Buscarinu, B Cerasoli, V Annibali, C Policano, L Lionetto, M Capi, ...
Multiple Sclerosis Journal 23 (3), 442-446, 2017
392017
Association of Rs7961894 with Mean Platelet Volume in Patients with Acute Ischemic Stroke
M Miller, N Henninger, R Umeton, A Slowik
Stroke 48, ATP202, 2017
2017
Gene-environment interaction study in multiple sclerosis using a" candidate-interactome" approach
R Mechelli, R Umeton, Imsgc-Wtccc, G Ristori, M Salvetti
MULTIPLE SCLEROSIS JOURNAL 22, 191-192, 2016
2016
Epstein barr virus genotipic variants and uses thereof as risk predictors, biomarkers and therapeutic targets in multiple sclerosis
G Ristori, R Mechelli, M Salvetti, C Policano, R Umeton
US Patent App. 14/782,556, 2016
2016
Portable medical device and method for quantitative retinal image analysis through a smartphone
C Stamile, R Umeton, M Cavallari, F Calimeri, F Orzi
US Patent 20150320313A1, 2016
12016
IFN-β and multiple sclerosis: from etiology to therapy and back
V Annibali, R Mechelli, S Romano, MC Buscarinu, A Fornasiero, ...
Cytokine & growth factor reviews 26 (2), 221-228, 2015
242015
Epstein-Barr virus genetic variants are associated with multiple sclerosis.
R Mechelli, C Manzari, C Policano, A Annese, E Picardi, R Umeton, ...
Neurology 31 (84), 1362-8, 2015
262015
Novel method for automated analysis of retinal images: results in subjects with hypertensive retinopathy and CADASIL
M Cavallari, C Stamile, R Umeton, F Calimeri, F Orzi
BioMed research international 2015, 2015
172015
B cell IRF1 pathway is dysregulated in multiple sclerosis
V Annibali, R Umeton, A Palermo, MC Buscarinu, C Policano, R Mechelli, ...
Journal of Neuroimmunology 275 (1), 1, 2014
2014
Noise in multiple sclerosis: unwanted and necessary
I Bordi, VAG Ricigliano, R Umeton, G Ristori, F Grassi, A Crisanti, ...
Annals of clinical and translational neurology 1 (7), 502-511, 2014
32014
Optimization and Ontology for Computational Systems Biology
R Umeton, S Di Gregorio, G Nicosia
2014
Drug repositioning and computational analysis for myelin disease regenerative therapies
C Eleuteri, C Veroni, M Floris, S Olla, R Umeton, G Ristori, V Annibali, ...
MULTIPLE SCLEROSIS JOURNAL 19 (11), 163-163, 2013
2013
Contribution of genome-wide association studies to scientific research: a pragmatic approach to evaluate their impact
VAG Ricigliano, R Umeton, L Germinario, E Alma, M Briani, N Di Segni, ...
PloS one 8 (8), e71198, 2013
82013
In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology
A Koo, D Nordsletten, R Umeton, et al.
Biophysical journal 104 (10), 2295-2306, 2013
252013
A “candidate-interactome” aggregate analysis of genome-wide association data in multiple sclerosis
R Mechelli, R Umeton, C Policano, V Annibali, G Coarelli, VAG Ricigliano, ...
PLoS One 8 (5), e63300, 2013
232013
Automated analysis of retinal photographs: results in subjects with hypertensive retinopathy and CADASIL
M Cavallari, C Stamile, R Umeton, F Orzi
NEUROLOGY 80, 2013
12013
Automated Analysis of Retinal Photographs: Results in Subjects with Hypertensive Retinopathy and CADASIL (P06. 009)
M Cavallari, C Stamile, R Umeton, F Orzi
Neurology 80 (7 Supplement), P06. 009-P06. 009, 2013
2013
Efficient behavior of photosynthetic organelles via Pareto optimality, identifiability, and sensitivity analysis
G Carapezza, R Umeton, J Costanza, C Angione, G Stracquadanio, ...
ACS synthetic biology 2 (5), 274-288, 2013
102013
A ‘‘Candidate-Interactome’’Aggregate Analysis of Genome-Wide Association Data
R Mechelli, R Umeton, C Policano, V Annibali, G Coarelli
2013
A mechanistic, stochastic model helps understand multiple sclerosis course and pathogenesis
I Bordi, R Umeton, VAG Ricigliano, V Annibali, R Mechelli, G Ristori, ...
International journal of genomics 2013, 2013
142013
Transciptome of B lymphocytes in multiple sclerosis
V Annibali, R Umeton, A Annese, A Palermo, R Mechelli, C Policano, ...
JOURNAL OF NEUROIMMUNOLOGY 253 (1-2), 9-9, 2012
2012
OREMPdb: a semantic dictionary of computational pathway models
R Umeton, G Nicosia, CF Dewey
BMC bioinformatics 13 (4), S6, 2012
82012
New enhancers of endogenous remyelination: an extensive in vitro and ex vivo screening
C Eleuteri, C Veroni, R Umeton, V Annibali, G Ristori, M Salvetti, C Agresti
28th Congress of the European Committee for Treatment and Research in …, 2012
22012
Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood
R Calabrese, M Zampieri, R Mechelli, V Annibali, T Guastafierro, ...
Multiple Sclerosis Journal 18 (3), 299-304, 2012
492012
metaDesign: Bacterial Strain Design Automation Software
C Jole, C Giovanni, A Claudio, U Renato, L Pietro, G Nicosia
IWBDA 2012, 2012
2012
Identification of sensitive enzymes in the photosynthetic carbon metabolism
R Umeton, G Stracquadanio, A Papini, J Costanza, P Lio, G Nicosia
Advances in Systems Biology, 441-459, 2012
52012
Design of robust metabolic pathways
R Umeton, G Stracquadanio, A Sorathiya, A Papini, P Liò, G Nicosia
2011 48th ACM/EDAC/IEEE Design Automation Conference (DAC), 747-752, 2011
112011
Semantic Queries for Biomedical Pathways
R Umeton, G Nicosia, CF Dewey Jr
10th Workshop on Process Algebra and Stochastically Timed Activities (PASTA …, 2011
2011
Multi-scale Mathematical Modeling to Support Drug Development
DA Nordsletten, BY Yankama, R Umeton, et al.
IEEE Transactions on Biomedical Engineering, 2011
42011
Large scale agent-based modeling of the humoral and cellular immune response
G Stracquadanio, R Umeton, J Costanza, V Annibali, R Mechelli, ...
International Conference on Artificial Immune Systems (ICARIS 2011), 15-29, 2011
22011
ORES-2010 Ontology Repositories and Editors for the Semantic Web
M d'Aquin, AG Castro, C Lange, K Viljanen
32010
Analysis and optimization of c3 photosynthetic carbon metabolism
G Stracquadanio, R Umeton, A Papini, P Lio, G Nicosia
2010 IEEE International Conference on BioInformatics and BioEngineering, 44-51, 2010
142010
A Cross-Format Framework for Consistent Information Integration among Molecular Pathways and Ontologies
R Umeton, B Yankama, G Nicosia, CF Dewey
6th World Congress of Biomechanics (WCB 2010). August 1-6, 2010 Singapore …, 2010
22010
Key Enzymes for the optimization of CO2 uptake and nitrogen consumption in the C3 photosynthetic carbon metabolism
A Papini, G Nicosia, G Stracquadanio, P Lio, R Umeton
Journal of Biotechnology, 525-526, 2010
32010
OREMP: Ontology Reasoning Engine for Molecular Pathways
R Umeton, B Yankama, G Nicosia, CF Dewey Jr
1st International Workshop on Ontology Repositories and Editors for the …, 2010
12010
Highway traffic model based on cellular automata: Preliminary simulation results with congestion pricing considerations
S Di Gregorio, R Umeton, A Bicocchi, A Evangelisti, MC Gonzalez
20th European Modeling and Simulation Symposium, EMSS 2008, 17-19 September …, 2008
22008
A CELLULAR AUTOMATA MODEL FOR HIGHWAY TRAFFIC WITH PRELIMINARY RESULTS
S Di Gregorio, R Umeton, A Bicocchi, A Evangelisti
Artificial Life and Evolutionary Computation: Proceedings of Wivace 2008, 235, 2008
2008
“ADMISSIBLE METHOD FOR IMPROVED GENETIC SEARCH IN CELLULAR AUTOMATA MODEL (AMMISCA)”: A STRATEGY IN GENETIC CALIBRATION-PRELIMINARY RESULTS
R UMETON, S DI GREGORIO
Artificial Life and Evolutionary Computation: Proceedings of Wivace 2008, 99, 2008
2008
Efficient Behavior of Photosynthetic Organelles via Pareto Optimality, Identifiability and Sensitivity Analysis-Appendix Supplementary Information
G Carapezza, R Umeton, J Costanza, C Angione, G Stracquadanio, ...
1
Modeling and Optimization of Efficient Photosynthetic Organelles-Appendix Supplementary Information
G Carapezza, R Umeton, J Costanza, C Angione, G Stracquadanio, ...
OREMPdb: a Semantic Dictionary of Runnable Biological Circuits
R Umeton, G Nicosia, CF Dewey Jr