New Papers and Preprints : On synthesizing heterogeneous single-cell modalities (Genome Biology), and on predicting protein-protein interactions from sequence data (RECOMB).
News: In Jan 2021 (and previously in Jan 2020), I taught an IAP course, The Business of Quant Investing. The syllabus for this class and other related information is available here.

I am a Research Scientist at CSAIL. My research interests broadly lie in the area of computational biology. Within this, I have worked on a diverse set of research topics, ranging from protein structure prediction to experiment design. I am currently working on a few projects, including methods for analyzing single-cell experimental data and de novo prediction of protein-protein interactions. My PhD dissertation, on algorithms for analyzing protein interaction networks, is available here. My collaborators and I were honored to receive the Test of Time Award at RECOMB 2019 for the work we have done in this field (specifically, the IsoRank algorithm for global alignment of protein interaction networks).


Between my two stints at MIT, first as a PhD candidate and now as a Research Scientist, I've spent about a decade working in quantitative trading (LinkedIn profile). Most recently, I was the CEO of Tech Square Trading, a Boston-based quantitative hedge fund that I co-founded. Before that, I worked at Merrill Lynch and Cubist Systematic. The fields of quant investing and computational biology turn out to require surprisingly similar skills: an expertise in working with large amounts of very messy data and an ability to design robust models that can explain the data. I very much enjoyed the research problems in quant investing and continue to think about them. If you are a quant practitioner who would like to compare notes, I would be delighted to connect!


I received my PhD at MIT under the guidance of Prof. Bonnie Berger. Between my Masters and my PhD, I worked for a year at Accelrys, a bioinformatics & cheminformatics company. They are now part of Dassault Systemes. I received a Masters degree from Stanford University, where I was part of Prof. Jean-Claude Latombe's group. I received my undergraduate degree from Indian Institute of Technology, Kanpur and went to high school in Bhilai, a smallish town in central India. I used to blog fairly actively, though I haven't gotten back to it in a long while.

Rohit Singh