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Renato Umeton, Ph.D.

Data Science, Machine Learning, Optimization, Biostatistics.

 

PublicationsYear
Machine Learning, Optimization, and Data Science (4th International Conference, LOD 2018, Volterra, Italy, September 13-16, 2018, Revised Selected Papers)
G Nicosia, P Pardalos, G Giuffrida, R Umeton, V Sciacca
Book - Springer 11331, 1-584, 2019
2019
Use of targeted next generation sequencing to characterize tumor mutational burden and efficacy of immune checkpoint inhibition in small cell lung cancer
B Ricciuti, S Kravets, SE Dahlberg, R Umeton, A Albayrak, SJ Subegdjo, ...
Journal for ImmunoTherapy of Cancer 7 (1), 87-96, 2019
2019
Inter-test variability in tumor mutational burden (TMB) quantification and identification of TMB thresholds
N Vokes, EJ Alguilar, R Umeton, A Adeni, L Sholl, M Hellmann, H Rizvi, ...
Cancer Research 79 (13), 2514, 2019
2019
Impact of KRAS allele subtypes and concurrent genomic alterations on clinical outcomes to programmed death 1 axis blockade in non-small cell lung cancer.
B Ricciuti, G Recondo, R Umeton, M Nishino, LM Sholl, MM Awad
Journal of Clinical Oncology 37, 9082, 2019
2019
DNA damage response gene alterations are associated with high tumor mutational burden and clinical benefit from programmed death 1 axis inhibition in non-small cell lung cancer.
B Ricciuti, ML Cheng, G Recondo, M Nishino, R Umeton, LM Sholl, ...
Journal of Clinical Oncology 37, 9077, 2019
2019
Mutational analysis of 472 urothelial carcinoma across grades and anatomic sites
AH Nassar, R Umeton, J Kim, K Lundgren, L Harshman, EM Van Allen, ...
Clinical Cancer Research 25 (8), 2458-2470, 2019
42019
PTEN alterations and tumor mutational burden as potential predictors of resistance or response to immune checkpoint inhibitors in metastatic triple-negative breast cancer
R Barroso-Sousa, S Tyekucheva, S Pernas-Simon, P Exman, E Jain, ...
Cancer Research 79, P5, 2019
2019
Significant enrichment of Herpesvirus interactors in GWAS data suggests causal inferences for the association between Epstein Barr virus and multiple sclerosis
R Mechelli, R Umeton, S Srinivasan, A Fornasiero, M Ferraldeschi, ...
bioRxiv, 624049, 2019
2019
Genome-Wide Multiple Sclerosis Association Data and Coagulation
S La Starza, M Ferraldeschi, MC Buscarinu, S Romano, A Fornasiero, ...
Frontiers in Neurology 10, 95-101, 2019
12019
Machine Learning, Optimization, and Big Data (Third International Conference, MOD 2017, Volterra, Italy, September 14–17, 2017, Revised Selected Papers)
G Nicosia, P Pardalos, G Giuffrida, R Umeton
Book - Springer 10710, 1-621, 2018
12018
Use of Tumor-Only Next Generation Sequencing to Identify Clinicopathologic and Genomic Correlates of Tumor Mutational Burden and Immunotherapy Response in Non-Small Cell Lung …
M Awad, NR Mahadevan, A Polio, EJ Aguilar, NI Vokes, B Ricciuti, ...
2018
Efficacy and Genomic Correlates of Response to Anti-PD1/PD-L1 Blockade in Non-Small Cell Lung Cancers Harboring Targetable Oncogenes
N Vokes, EJ Alguilar, A Adeni, R Umeton, L Sholl, H Rizvi, M Hellmann, ...
Journal of Thoracic Oncology 13 (10), S422, 2018
12018
PD-L1 Expression, Tumor Mutational Burden, and Response to Immunotherapy in Patients with MET exon 14 Altered Lung Cancers
JK Sabari, GC Leonardi, CA Shu, R Umeton, J Montecalvo, A Ni, R Chen, ...
Annals of Oncology, 2018
102018
Comprehensive genomic characterization of urothelial carcinomas
A Nassar, R Umeton, K Lundgren, LC Harshman, EM Van Allen, ...
Journal of Clinical Oncology 36 (15), 4527, 2018
2018
Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade
IF Dunn, Z Du, M Touat, MB Sisti, PY Wen, R Umeton, AM Dubuc, ...
JCO precision oncology 2018, 2018
32018
Fractal analysis of retinal vascular morphology in multiple sclerosis
M Cavallari, D Kimbrough, C Stamile, R Umeton, T Chitnis, C Guttmann
MULTIPLE SCLEROSIS JOURNAL 24, 370-371, 2018
2018
Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients
V Annibali, R Umeton, A Palermo, M Severa, MP Etna, S Giglio, ...
Journal of neuroimmunology 324, 165-171, 2018
12018
Intestinal Permeability in Relapsing-Remitting Multiple Sclerosis
MC Buscarinu, S Romano, R Mechelli, RP Umeton, M Ferraldeschi, ...
Neurotherapeutics, 1-7, 2018
122018
Somatic mutations in CDH1 and CTNNB1 in primary carcinomas at 13 anatomic sites
EL Busch, JL Hornick, R Umeton, A Albayrak, NI Lindeman, ...
Oncotarget 8 (49), 85680, 2017
22017
Different environmental stimuli may activate common biological processes potentially involved in multiple sclerosis
R Mechelli, R Umeton, R Renie, G Ristori, M Salvetti
MULTIPLE SCLEROSIS JOURNAL 23, 210, 2017
2017
The gut microbiome in active and stable relapsing multiple sclerosis
E Eleftheriou, RP Umeton, R Umeton, S Nedelcu, AL Contreras, L Hall, ...
MULTIPLE SCLEROSIS JOURNAL 23, 518, 2017
2017
A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials
C Eleuteri, S Olla, C Veroni, R Umeton, R Mechelli, S Romano, ...
Nature Scientific Reports 7 (www.nature.com/articles/srep45780), 45780, 2017
92017
Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study
MC Buscarinu, B Cerasoli, V Annibali, C Policano, L Lionetto, M Capi, ...
Multiple Sclerosis Journal 23 (3), 442-446, 2017
412017
Abstract TP202
M Miller, N Henninger, R Umeton, A Slowik
Stroke 48 (Suppl_1), 2017
2017
Association of Rs7961894 with Mean Platelet Volume in Patients with Acute Ischemic Stroke
M Miller, N Henninger, R Umeton, A Slowik
Stroke 48, ATP202, 2017
2017
Gene-environment interaction study in multiple sclerosis using a" candidate-interactome" approach
R Mechelli, R Umeton, Imsgc-Wtccc, G Ristori, M Salvetti
MULTIPLE SCLEROSIS JOURNAL 22, 191-192, 2016
2016
Epstein barr virus genotipic variants and uses thereof as risk predictors, biomarkers and therapeutic targets in multiple sclerosis
G Ristori, R Mechelli, M Salvetti, C Policano, R Umeton
US Patent App. 14/782,556, 2016
2016
Portable medical device and method for quantitative retinal image analysis through a smartphone
C Stamile, R Umeton, M Cavallari, F Calimeri, F Orzi
US Patent 20150320313A1, 2016
12016
IFN-β and multiple sclerosis: from etiology to therapy and back
V Annibali, R Mechelli, S Romano, MC Buscarinu, A Fornasiero, ...
Cytokine & growth factor reviews 26 (2), 221-228, 2015
262015
Epstein-Barr virus genetic variants are associated with multiple sclerosis.
R Mechelli, C Manzari, C Policano, A Annese, E Picardi, R Umeton, ...
Neurology 31 (84), 1362-8, 2015
272015
Novel method for automated analysis of retinal images: results in subjects with hypertensive retinopathy and CADASIL
M Cavallari, C Stamile, R Umeton, F Calimeri, F Orzi
BioMed research international 2015, 2015
172015
B cell IRF1 pathway is dysregulated in multiple sclerosis
V Annibali, R Umeton, A Palermo, MC Buscarinu, C Policano, R Mechelli, ...
Journal of Neuroimmunology 275 (1), 1, 2014
2014
Noise in multiple sclerosis: unwanted and necessary
I Bordi, VAG Ricigliano, R Umeton, G Ristori, F Grassi, A Crisanti, ...
Annals of clinical and translational neurology 1 (7), 502-511, 2014
32014
Optimization and Ontology for Computational Systems Biology
R Umeton, S Di Gregorio, G Nicosia
2014
Drug repositioning and computational analysis for myelin disease regenerative therapies
C Eleuteri, C Veroni, M Floris, S Olla, R Umeton, G Ristori, V Annibali, ...
MULTIPLE SCLEROSIS JOURNAL 19 (11), 163-163, 2013
2013
Contribution of genome-wide association studies to scientific research: a pragmatic approach to evaluate their impact
VAG Ricigliano, R Umeton, L Germinario, E Alma, M Briani, N Di Segni, ...
PloS one 8 (8), e71198, 2013
82013
In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology
A Koo, D Nordsletten, R Umeton, et al.
Biophysical journal 104 (10), 2295-2306, 2013
262013
A “candidate-interactome” aggregate analysis of genome-wide association data in multiple sclerosis
R Mechelli, R Umeton, C Policano, V Annibali, G Coarelli, VAG Ricigliano, ...
PLoS One 8 (5), e63300, 2013
242013
Automated analysis of retinal photographs: results in subjects with hypertensive retinopathy and CADASIL
M Cavallari, C Stamile, R Umeton, F Orzi
NEUROLOGY 80, 2013
12013
Automated Analysis of Retinal Photographs: Results in Subjects with Hypertensive Retinopathy and CADASIL (P06. 009)
M Cavallari, C Stamile, R Umeton, F Orzi
Neurology 80 (7 Supplement), P06. 009-P06. 009, 2013
2013
Efficient behavior of photosynthetic organelles via Pareto optimality, identifiability, and sensitivity analysis
G Carapezza, R Umeton, J Costanza, C Angione, G Stracquadanio, ...
ACS synthetic biology 2 (5), 274-288, 2013
102013
Varianti genotipiche del virus di Epstein Barr e loro usi come possibili predittori di rischio, biomarcatori e target terapeutici nella sclerosi multipla
R Mechelli, C Policano, R Umeton, M Salvetti, G Ristori
2013
A ‘‘Candidate-Interactome’’Aggregate Analysis of Genome-Wide Association Data
R Mechelli, R Umeton, C Policano, V Annibali, G Coarelli
2013
A mechanistic, stochastic model helps understand multiple sclerosis course and pathogenesis
I Bordi, R Umeton, VAG Ricigliano, V Annibali, R Mechelli, G Ristori, ...
International journal of genomics 2013, 2013
132013
OREMPdb: a semantic dictionary of computational pathway models
R Umeton, G Nicosia, CF Dewey
BMC bioinformatics 13 (4), S6, 2012
72012
New enhancers of endogenous remyelination: an extensive in vitro and ex vivo screening
C Eleuteri, C Veroni, R Umeton, V Annibali, G Ristori, M Salvetti, C Agresti
28th Congress of the European Committee for Treatment and Research in …, 2012
22012
Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood
R Calabrese, M Zampieri, R Mechelli, V Annibali, T Guastafierro, ...
Multiple Sclerosis Journal 18 (3), 299-304, 2012
492012
Characterization of Epstein-Barr virus genotypes in multiple sclerosis
P Claudia, R Mechelli, M Caterina, P Ernesto, A Viviana, U Renato, ...
XXII° AINI Congress, 2012
2012
metaDesign: Bacterial Strain Design Automation Software
C Jole, C Giovanni, A Claudio, U Renato, L Pietro, G Nicosia
IWBDA 2012, 2012
2012
Transciptome of B lymphocytes in multiple sclerosis
A Viviana, U Renato, A Annese, A Palermo, R Mechelli, P Claudia, ...
11th International Congress of Neuroimmunology (ISNI) 253, 9-9, 2012
2012
Identification of sensitive enzymes in the photosynthetic carbon metabolism
R Umeton, G Stracquadanio, A Papini, J Costanza, P Lio, G Nicosia
Advances in Systems Biology, 441-459, 2012
52012
Design of robust metabolic pathways
R Umeton, G Stracquadanio, A Sorathiya, A Papini, P Liò, G Nicosia
2011 48th ACM/EDAC/IEEE Design Automation Conference (DAC), 747-752, 2011
112011
Semantic Queries for Biomedical Pathways
R Umeton, G Nicosia, CF Dewey Jr
10th Workshop on Process Algebra and Stochastically Timed Activities (PASTA …, 2011
2011
Multi-scale Mathematical Modeling to Support Drug Development
DA Nordsletten, BY Yankama, R Umeton, et al.
IEEE Transactions on Biomedical Engineering, 2011
42011
Large scale agent-based modeling of the humoral and cellular immune response
G Stracquadanio, R Umeton, J Costanza, V Annibali, R Mechelli, ...
International Conference on Artificial Immune Systems (ICARIS 2011), 15-29, 2011
22011
ORES-2010 Ontology Repositories and Editors for the Semantic Web
M d'Aquin, AG Castro, C Lange, K Viljanen
32010
Analysis and optimization of c3 photosynthetic carbon metabolism
G Stracquadanio, R Umeton, A Papini, P Lio, G Nicosia
2010 IEEE International Conference on BioInformatics and BioEngineering, 44-51, 2010
142010
A Cross-Format Framework for Consistent Information Integration among Molecular Pathways and Ontologies
R Umeton, B Yankama, G Nicosia, CF Dewey
6th World Congress of Biomechanics (WCB 2010). August 1-6, 2010 Singapore …, 2010
22010
Key Enzymes for the optimization of CO2 uptake and nitrogen consumption in the C3 photosynthetic carbon metabolism
A Papini, G Nicosia, G Stracquadanio, P Lio, R Umeton
Journal of Biotechnology, 525-526, 2010
32010
OREMP: Ontology Reasoning Engine for Molecular Pathways
R Umeton, B Yankama, G Nicosia, CF Dewey Jr
1st International Workshop on Ontology Repositories and Editors for the …, 2010
12010
Highway traffic model based on cellular automata: Preliminary simulation results with congestion pricing considerations
S Di Gregorio, R Umeton, A Bicocchi, A Evangelisti, MC Gonzalez
20th European Modeling and Simulation Symposium, EMSS 2008, 17-19 September …, 2008
22008
A CELLULAR AUTOMATA MODEL FOR HIGHWAY TRAFFIC WITH PRELIMINARY RESULTS
S Di Gregorio, R Umeton, A Bicocchi, A Evangelisti
Artificial Life and Evolutionary Computation: Proceedings of Wivace 2008, 235, 2008
2008
“ADMISSIBLE METHOD FOR IMPROVED GENETIC SEARCH IN CELLULAR AUTOMATA MODEL (AMMISCA)”: A STRATEGY IN GENETIC CALIBRATION-PRELIMINARY RESULTS
R UMETON, S DI GREGORIO
Artificial Life and Evolutionary Computation: Proceedings of Wivace 2008, 99, 2008
2008
Introduction of More Physical Features in the Cellular Automata Model for Lava Flows SCIARA: Preliminary Results Regarding the Viscosity
MV Avolio, GM Crisci, S Di Gregorio, R Rongo, R Umeton
Geophysical Research Abstracts / Proceedings of Asia Oceania Geosciences …, 2007
1*2007
Efficient Behavior of Photosynthetic Organelles via Pareto Optimality, Identifiability and Sensitivity Analysis-Appendix Supplementary Information
G Carapezza, R Umeton, J Costanza, C Angione, G Stracquadanio, ...
1
Modeling and Optimization of Efficient Photosynthetic Organelles-Appendix Supplementary Information
G Carapezza, R Umeton, J Costanza, C Angione, G Stracquadanio, ...
OREMPdb: a Semantic Dictionary of Runnable Biological Circuits
R Umeton, G Nicosia, CF Dewey Jr