Interferometric Synthetic Aperture Microscopy (ISAM) is a new imaging technique, which applies the inverse scattering solution to broadband coherent imaging, such as optical coherence tomography (OCT) [1].  ISAM was originally designed for real-time image-guided surgery to visualize microscopic tissue boundaries between cancerous and viable cells.  An ISAM system combines optical range profiles to form high-resolution images akin to Synthetic Aperture Radar (SAR) algorithms that are used for processing raw radar returns [2].  Similar to SAR and unlike OCT, ISAM systems provide spatially-invariant resolution, which is necessary for accurately measuring varying depths-of-field with high resolution.

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