Cortical Development, Plasticity, and Dynamics
Plasticity, or the adaptive response of the brain to changes in inputs, is essential to brain
development and function. The developing brain requires a genetic blueprint but is also acutely
sensitive to the environment. The adult brain constantly adapts to changes in stimuli, and this
plasticity is manifest not only as learning and memory but also as dynamic changes in information
transmission and processing. The goal of the Sur laboratory is to understand long-term plasticity
and short-term dynamics in networks of the developing and adult cortex. In addition, we aim to use
insights from brain development to understand mechanisms of developmental brain disorders.
Caggiano V, Sur M, Bizzi E.
Rostro-caudal inhibition of hindlimb movements in the spinal cord of mice.
PLoS One. 2014 Jun 25;9(6):e100865. doi: 10.1371/journal.pone.0100865. eCollection 2014. PMID: 24963653
Castro J, Garcia RI, Kwok S, Banerjee A, Petravicz J, Woodson J, Mellios N, Tropea D, and Sur M.
Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome.
PNAS Published online before print June 23, 2014, doi: 10.1073/pnas.1311685111.
Mellios N, Woodson J, Garcia RI, Crawford B, Sharma J, Sheridan SD, Haggarty SJ, and Sur M.
ß2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome.
PNAS Published online before print June 23, 2014, doi: 10.1073/pnas.1309426111.
Sharma J, Sugihara H, Katz Y, Schummers J, Tenenbaum J, Sur M.
Spatial Attention and Temporal Expectation Under Timed Uncertainty Predictably Modulate Neuronal Responses in Monkey V1.
Cereb Cortex. 2014 May 16. pii: bhu086. [Epub ahead of print] PMID: 24836689
Bosch M, Castro J, Saneyoshi T, Matsuno H, Sur M, Hayashi Y.
Structural and molecular remodeling of dendritic spine substructures during long-term potentiation.
2014 Apr 16;82(2):444-59. doi: 10.1016/j.neuron.2014.03.021. PMID: 24742465
El-Boustani S, Wilson NR, Runyan CA, Sur M.
El-Boustani et al. reply.
Nature. 2014 Apr 3;508(7494):E3-4. doi: 10.1038/nature13130. PMID: 24695315
Khwaja OS, Ho E, Barnes KV, O'Leary HM, Pereira LM, Finkelstein Y, Nelson CA 3rd, Vogel-Farley V, DeGregorio G, Holm IA, Khatwa U, Kapur K, Alexander ME, Finnegan DM, Cantwell NG, Walco AC, Rappaport L, Gregas M, Fichorova RN, Shannon MW, Sur M, Kaufmann WE.
Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome.
Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4596-601. doi: 10.1073/pnas.1311141111. Epub 2014 Mar 12. PMID: 24623853
Perea G, Yang A, Boyden E. and Sur M.
Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo.
Nature Communications 5: 3262, doi: 10.1038/
Two-way communication with neural networks in vivo using directed light.
Nature Protocols 8: 1184–1203 (2013).