Cortical Development, Plasticity, and Dynamics
Plasticity, or the adaptive response of the brain to changes in inputs, is essential to brain
development and function. The developing brain requires a genetic blueprint but is also acutely
sensitive to the environment. The adult brain constantly adapts to changes in stimuli, and this
plasticity is manifest not only as learning and memory but also as dynamic changes in information
transmission and processing. The goal of the Sur laboratory is to understand long-term plasticity
and short-term dynamics in networks of the developing and adult cortex. In addition, we aim to use
insights from brain development to understand mechanisms of developmental brain disorders.
Mechanisms and therapeutic challenges in autism spectrum disorders: insights from Rett syndrome.
Curr Opin Neurol. 2013 Apr;26(2):154-9. doi: 10.1097/WCO.0b013e32835f19a7.
Afferent specificity, feature specific connectivity influence orientation selectivity: A computational study in mouse primary visual cortex.
Nucleus basalis enabled stimulus specific plasticity in the visual cortex is mediated by astrocytes.
Proceedings of the National Academy of Sciences (doi: 10.1073/pnas.1206557109), 2012. [PDF]
Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes.
Cell Stem Cell 11: 75-90, 2012. [PDF]
Division and subtraction by distinct cortical inhibitory networks in vivo.
Nature 488: 343-348, 2012; doi:10.1038/nature11347. [PDF]
The emerging role of microRNAs in schizophrenia and autism spectrum disorders.
Front. Psychiatry 2012 April; 3:39. [PDF]