Consequences

Simulations were performed for TCRs of length N=5, with amino-acid compositions typical of human proteome.

 (Typical number of peptide encounters in thymus is 1,000-10,000)

The selection process biases the composition of amino-acids in mature TCRs:

Negative selection leads to a preference for weaker amino-acids.

This is more or less consistent with the limited available crystallographic data from TCR/peptide interfaces.

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Specificity of TCRs and transgenic mice:

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Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection:

Nature (2010)

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