ENS, Paris               Statistical physics methods in biology and computer science               July 15, 2016

Self-nonself discrimintion of T-cells:

Thymic Selection & Quorum Sensing

Abhishek Jha, Tom Butler

Andrej Kosmrlj, Hanrong Chen

Eugene Shakhnovich, Eric Huseby, Arup K. Chakraborty

Mehran Kardar (MIT)

Outline

I.       Introduction: T-cells, receptors, thymic selection                                       

II.      Model: binding, positive and negative selection

III.      Results: amino-acid bias, specificity and self-reactivity

IV.     Analysis: Exterme Value Distribution, exact results         

V.      Quorum sensing as a means for avoiding autoimmune response

VI.    Summary

Next (Introduction) Outline Introduction Model Results Analysis Quorum sensing Summary