Physics Colloquium                                 Univerity of California, San Diego                         24 January 2019

Diversity, tolerance, and maturation of the adaptive immune response

Andrej Kosmrlj, Hanrong Chen

Tom Butler, John Barton, Assaf Amitai, Shenshen Wang

A. Jha, E. Shakhnovich, E. Huseby, Arup K. Chakraborty

Mehran Kardar (MIT)

Outline

I.       The adaptive immune system: B cells, T cells- diverse, self-tolerant, and specific                                       

II.      Thymic Selection: positive and negative selection, specificity from weak amino-acids, extreme value distribution

III.     Quorum sensing for peripheral tolerance

IV.     Affinity Maturation: Dependence of affinity on target density

V.       Broadly neutralizing Antibodies: Sequential versus cocktail administration of antigen variants

VI.    Dynamics of HIV on a fitness landscape: Maximum entropy construction, mean-field approach

VII.   Summary

Next (Adaptive immunity) Outline Adaptive Immunity Thymic Selection Quorum sensing Affinity Maturation Broadly neutralizing Abs EMF dynamics Summary