Dresden                     MPI-PKS colloquium                 July 21, 2025

Specificity and tolerance of the immune T cell repertoire

Andrej Kosmrlj, Hanrong Chen, Tom Butler, Arup K. Chakraborty

Mehran Kardar (MIT)

Outline

I.      The adaptive immune syste: T cells, antigen presentation, specificity and tolerance                                       

II.      Thymic Selection: positive and negative selection, specificity from weak amino-acids, extreme value distribution

III.     Quorum Sensing for peripheral tolerance

IV.     Persistent infections and onset of autoimmunity

V.      Summary

Next (Adaptive Immunity) Outline Adaptive Immune system Central tolerance Peripheral tolerance Persistent Infections Summary