Summary

I.       Introduction: B cells, Antibodies and Antigens                      

         the puzzle of low HIV spike density                           

II.      Affinity Maturation: Evolution in the Germinal Center 

III.      Fitness & Evolution: Competition for virus capture

dependence of potency on spike density   

IV.     Optimal density for synthetic nano-particle vaccination; increased competition in HIV

V.       Broadly neutralizing Antibodies: Controlling affinity maturation against a mutable virus

        vs.         

MIT Club of DC                             May 1, 2023

                Assaf Amitai            Shenshen Wang    Arup K. Chakraborty      

Next (Introduction) Outline Introduction Affinity Maturation Fitness & Evolution Optimal density Broadly neutralizing Abs Multiple Ag Summary