Summary

I.       Introduction: B cells, Antibodies and antigens                      

         the puzzle of low HIV spike density                           

II.      Affinity Maturation: Evolution in the Germinal Center 

III.      Fitness & Evolution: Competition for virus capture

dependence of potency on spike density   

IV.     Optimal density for synthetic nanoparticle vaccination; increased competition in HIV

A. Amitai, A.K. Chakraborty, M. Kardar PLOS Comp. Bio. doi.org/10.1371/journal.pcbi.1006408

V.       Broadly neutralizing Antibodies: Controlling affinity maturation against a mutable virus

vs.

VI.    Affinity Maturation with Multiple Antigens

Kadir Has University                     Online Colloquium               3 June 2020

                Assaf Amitai            Shenshen Wang    Arup K. Chakraborty      

              Hanrong Chen     John Barton                   Scott Shaffer       Penny Moore                          

Next (Introduction) Outline Introduction Affinity Maturation Fitness & Evolution Optimal density Broadly neutralizing Abs Multiple Ag Summary