Summary

I.       The adaptive immune system: B cells, T cells- diverse, self-tolerant, and specific 

II.      Thymic Selection: positive and negative selection, specificity from weak amino-acids, extreme value distribution

III.     Quorum sensing for peripheral tolerance                                              

IV.     B cells: B cells, Antibodies and Antigens                      

         the puzzle of low HIV spike density                           

V.      Affinity Maturation: Evolution in the Germinal Center 

VI.      Fitness & Evolution: Competition for virus capture

dependence of potency on spike density   

VII.     Optimal density for synthetic nanoparticle vaccination; increased competition in HIV

A. Amitai, A.K. Chakraborty, M. Kardar PLOS Comp. Bio. doi.org/10.1371/journal.pcbi.1006408

VIII.       Broadly neutralizing Antibodies: Controlling affinity maturation against a mutable virus

        vs.         

IX.    Affinity Maturation with Multiple Antigens

Arup K. Chakraborty 

T cell projects:

Andrej Kosmrlj,    Hanrong Chen,    Tom Butler,           Sam Melton,         Rose Yin               

(A. Jha, E. Shakhnovich, E. Huseby)

B cell projects:

Shenshen Wang,      Assaf Amitai,       Saeed Mahdisoltani,  Federica Ferretti    

Cambridge University                               TCM seminar                           9 November 2023

Next (Adaptive immunity) Outline Adaptive Immunity Thymic Selection Quorum sensing Affinity Maturation Broadly neutralizing Abs EMF dynamics Summary