Summary
I. Introduction: B cells, Antibodies and Antigens
the puzzle of low HIV spike density
II. Affinity Maturation: Evolution in the Germinal Center 
III. Fitness & Evolution: Competition for virus capture 
dependence of potency on spike density
IV. Optimal density for synthetic nanoparticle vaccination; increased competition in HIV
A. Amitai, A.K. Chakraborty, M. Kardar PLOS Comp. Bio. doi.org/10.1371/journal.pcbi.1006408
V. Broadly neutralizing Antibodies: Controlling affinity maturation against a mutable virus
vs. 
VI. Affinity Maturation with Multiple Antigens
DAMPT, Cambridge Biolunch seminar December 14, 2023
Assaf Amitai Shenshen Wang Arup K. Chakraborty
