Summary

I.       Introduction: B cells, Antibodies and Antigens                      

         the puzzle of low HIV spike density                           

II.      Affinity Maturation: Evolution in the Germinal Center 

III.      Fitness & Evolution: Competition for virus capture

dependence of potency on spike density   

IV.     Optimal density for synthetic nanoparticle vaccination; increased competition in HIV

A. Amitai, A.K. Chakraborty, M. Kardar PLOS Comp. Bio. doi.org/10.1371/journal.pcbi.1006408

V.       Broadly neutralizing Antibodies: Controlling affinity maturation against a mutable virus

        vs.         

VI.    Affinity Maturation with Multiple Antigens

APS meeting, Las Vegas                Delbruck Prize Symposium                 March 8, 2023

                Assaf Amitai            Shenshen Wang    Arup K. Chakraborty      

Saeed Mahdisoltani

Federica Ferretti 

Next (Introduction) Outline Introduction Affinity Maturation Fitness & Evolution Optimal density Broadly neutralizing Abs Multiple Ag Summary