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AFVP - A Realistic Ventricular Rhythm Model During AF

AFVP generates a synthesized beat-to-beat interval sequence of ventricular excitations with a realistic structure observed during AF. The AV junction (AVJ) is treated as a lumped structure characterized by refractoriness and automaticity. Bombarded by random AF impulses, the AVJ can also be invaded by the VP-induced retrograde wave. The model includes bi-directional conduction delays in the AVJ and ventricle. Both refractory period and conduction delay of the AVJ are dependent upon its recovery time. The electrotonic modulation by blocked impulses is also considered in the model. With proper parameter settings, the model can account for most principal statistical properties of the RR intervals during AF. AFVP was contributed to PhysioNet by Jie Lian, Dirk Müessig, and Volker Lang, all from Micro Systems Engineering, Inc., a subsidiary of Biotronik GmbH. The source code is freely available as a set of ANSI C-files.

The routines used by AFVP are described in

Lian J., Müssig D., Lang V. Computer Modeling of Ventricular Rhythm During Atrial Fibrillation and Ventricular Pacing. IEEE Transactions on Biomedical Engineering 53(8): 1512-1520, 2006.

Of related interest is the set of RR interval generators, entered in the Computers in Cardiology Challenege, 2002. These C-code algorithms were attempts to answer the question: Can you construct a simulation of the RR interval time series spanning a full 24 hours with sufficient verisimilitude to be taken as real? Can you classify a mixed set of real and simulated RR interval time series?

Updated Wednesday, 16 August 2006 at 16:44 EST