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Publications about 'epidemics'
Articles in journal or book chapters
  1. M.A. Al-Radhawi, M. Sadeghi, and E.D. Sontag. Long-term regulation of prolonged epidemic outbreaks in large populations via adaptive control: a singular perturbation approach. IEEE Control Systems Letters, 6:578-583, 2022. [PDF] Keyword(s): epidemiology, COVID-19, COVID, systems biology.
    Abstract:
    In order to control highly-contagious and prolonged outbreaks, public health authorities intervene to institute social distancing, lock-down policies, and other Non-Pharmaceutical Interventions (NPIs). Given the high social, educational, psychological, and economic costs of NPIs, authorities tune them, alternatively tightening up or relaxing rules, with the result that, in effect, a relatively flat infection rate results. For example, during the summer of 2020 in parts of the United States, daily COVID-19 infection numbers dropped to a plateau. This paper approaches NPI tuning as a control-theoretic problem, starting from a simple dynamic model for social distancing based on the classical SIR epidemics model. Using a singular-perturbation approach, the plateau becomes a Quasi-Steady-State (QSS) of a reduced two-dimensional SIR model regulated by adaptive dynamic feedback. It is shown that the QSS can be assigned and it is globally asymptotically stable. Interestingly, the dynamic model for social distancing can be interpreted as a nonlinear integral controller. Problems of data fitting and parameter identifiability are also studied for this model. This letter also discusses how this simple model allows for a meaningful study of the effect of population size, vaccinations, and the emergence of second waves.


  2. E. A. Hernandez-Vargas, G. Giordano, E.D. Sontag, J. G. Chase, H. Chang, and A. Astolfi. Second special section on systems and control research efforts against COVID-19 and future pandemics. Annual Reviews in Control, 51:424-425, 2021. [WWW] [doi:https://doi.org/10.1016/j.arcontrol.2021.04.005] Keyword(s): COVID-19, epidemiology, epidemics.


  3. E. A. Hernandez-Vargas, G. Giordano, E.D. Sontag, J. G. Chase, H. Chang, and A. Astolfi. Third special section on systems and control research efforts against COVID-19 and future pandemics. Annual Reviews in Control, 52:446-447, 2021. [WWW] [doi:https://doi.org/10.1016/j.arcontrol.2021.10.015] Keyword(s): COVID-19, epidemiology, epidemics.


  4. E.D. Sontag. An explicit formula for minimizing the infected peak in an SIR epidemic model when using a fixed number of complete lockdowns. International Journal of Robust and Nonlinear Control, Special Issue on Control-Theoretic Approaches for Systems in the Life Sciences, pp 1-24, 2021. [PDF] Keyword(s): epidemiology, COVID-19, COVID, systems biology, epidemics.
    Abstract:
    Careful timing of NPIs (non-pharmaceutical interventions) such as social distancing may avoid high ``second waves'' of infections of COVID-19. This paper asks what should be the timing of a set of K complete-lockdowns of prespecified lengths (such as two weeks) so as to minimize the peak of the infective compartment. Perhaps surprisingly, it is possible to give an explicit and easily computable rule for when each lockdown should commence. Simulations are used to show that the rule remains fairly accurate even if lockdowns are not perfect.


  5. E.A. Hernandez-Vargas, G. Giordano, E. D. Sontag, J. G. Chase, H. Chang, and A. Astolfi. First special section on systems and control research efforts against COVID-19 and future pandemics. Annual Reviews in Control, 50:343-344, 2020. [WWW] [doi:https://doi.org/10.1016/j.arcontrol.2020.10.007] Keyword(s): SARS-CoV-2, COVID-19, Modelling, Control, Pandemics, epidemics, epidemiology.


  6. E. A. Hernandez-Vargas, G. Giordano, E.D. Sontag, J. G. Chase, H. Chang, and A. Astolfi. First special section on systems and control research efforts against COVID-19 and future pandemics. Annual Reviews in Control, 50:343-344, 2020. [WWW] [doi:https://doi.org/10.1016/j.arcontrol.2020.10.007] Keyword(s): COVID-19, epidemiology, epidemics.



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