I am a postdoctoral researcher in the Department of Biology at MIT, working with Christopher Burge and funded by a Jane Coffin Childs postdoctoral fellowship. I received my Ph.D. in September 2012 from the Department of Human Genetics at the University of Chicago, working with Yoav Gilad and collaborating closely with Jonathan Pritchard's group.

My research interests lie in mammalian functional genomics, with a focus on understanding molecular mechanisms regulating gene expression variation across cells, tissues, individuals, and species. To address related questions within this area, I use a combination of experimental and computational approaches.

Research

In my graduate work, I uncovered the extent to which genetic and epigenetic regulatory mechanisms influenced variation in gene expression across primate species and within human populations. While these studies represented first steps towards elucidating the relative impacts of variation in specific cellular processes, our broader understanding was limited by focusing on singular mechanisms. During my postdoc, I have become interested in untangling the complexities of how different molecular mechanisms are coordinately regulated to influence gene expression outcomes, specifically focusing on mechanisms working in coordination with RNA splicing processes.

Overall, my research is driven by a conviction that characterizing cellular phenomenona on a genome-wide level will allow us to gain insights into basic principles of the genetic mutational landscape and the molecular interactions governing phenotypic outcomes. I have been strongly influenced by my training in mammalian experimental genomics, computational biology, and human genetics, with forays into using comparative/population genomics, statistical genetics, and anthropological approaches.

Specific research interests currently include:

  • Global biases in isoform regulation along a developmental axis
  • Variance in trans-regulatory factors: regulated or stochastic?
  • Relative rates of concerted RNA processing mechanims
  • Genetic basis for alternative isoform usage in the immune system

Publications

Google Scholar profile | Publications in Pubmed

Selected Publications

Curriculum Vitae

Department of Biology, MIT
31 Ames Street, 68-253
Cambridge, MA 02139

Education:

Ph.D. in Human Genetics (2007-2012)
University of Chicago, Chicago, IL

B.A. in Biochemistry & Anthropology, minor in South Asian Studies (2003-2007)
University of Pennsylvania, Philadelphia, PA

Academic and Research Experience:

2012-present Postdoctoral Researcher (advisor: Christopher Burge)
Jane Coffin Childs Memorial Fund Postdoctoral Fellow
Department of Biology, Massachusetts Institute of Technology

2007-2012 Graduate Student (advisor: Yoav Gilad)
American Heart Association Predoctoral Fellow
Department of Human Genetics, University of Chicago

2005-2007 Undergraduate Researcher (advisor: Theodore Schurr)
Nassau Fund & College Alumni Society Research Awardee
Laboratory of Molecular Anthropology
Department of Anthropology, University of Pennsylvania

2006 Summer Research Intern, Dept. of CNS
Discovery Biology, Pfizer Global R&D, Groton, CT

2005 Summer Research Assistant (advisor: Nancy Spinner)
Department of Human Genetics
Children's Hospital of Philadelphia (CHOP), Philadelphia, PA

Detailed CV available on request