**** MATERIAL SAFETY DATA SHEET **** **** MATERIAL SAFETY DATA SHEET ****

Caffeine
00347


**** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****


MSDS Name: Caffeine

**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 58-08-2 |CAFFEINE, 98% (TITR.) | 98 | 200-362-1 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T
Risk Phrases: 22

**** SECTION 3 - HAZARDS IDENTIFICATION ****

EMERGENCY OVERVIEW

Warning! May cause respiratory tract irritation. Harmful if
swallowed. May cause eye and skin irritation. May cause cardiac
disturbances. Can cause reproductive effects. May cause digestive
tract irritation with nausea, vomiting, and diarrhea. May cause
cancer based on animal studies.
Target Organs: Heart, central nervous system.

Potential Health Effects
Eye:
Dust may cause mechanical irritation.
Skin:
May cause skin irritation.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with
nausea, vomiting and diarrhea.
May cause ataxia, blood pressure elevation, convulsions,
hallucinations, hypermotility, muscle contraction or spasticity,
somnolence (general depressed activity), toxic psychosis, and
tremors.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to
those described for ingestion.
Chronic:
May cause cancer according to animal studies. May cause digestive
tract and cardiac disturbances. May cause reproductive and fetal
effects.

**** SECTION 4 - FIRST AID MEASURES ****

Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower lids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes
while removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists.
Ingestion:
Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls
of milk or water. Never give anything by mouth to an unconscious
person. Get medical aid immediately.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

**** SECTION 5 - FIRE FIGHTING MEASURES ****

General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.

**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Sweep up, then place into a suitable container for disposal. Avoid
generating dusty conditions.

**** SECTION 7 - HANDLING and STORAGE ****

Handling:
Wash hands before eating. Use with adequate ventilation. Avoid
contact with skin and eyes. Do not ingest or inhale.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits.

Personal Protective Equipment

Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29CFR
1910.134. Always use a NIOSH-approved respirator when
necessary.

**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State: Solid
Appearance: Not available.
Odor: Odorless.
pH: Not available.
Vapor Pressure: Negligible.
Vapor Density: Not available.
Evaporation Rate: Negligible.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 237.00!C
Decomposition Temperature: Not available.
Solubility: Not available.
Specific Gravity/Density: 1.2300g/cm3
Molecular Formula: C8H10N4O2
Molecular Weight: 194.19


**** SECTION 11 - TOXICOLOGICAL INFORMATION ****

RTECS#:
CAS# 58-08-2: EV6475000
LD50/LC50:
CAS# 58-08-2: Oral, mouse: LD50 = 127 mg/kg; Oral, rabbit: LD50 =
224 mg/kg; Oral, rat: LD50 = 192 mg/kg.
Carcinogenicity:
CAFFEINE, 98% (TITR.) -
IARC: Group 3 carcinogen
Epidemiology:
No data available.
Teratogenicity:
A human teratogen, causes developmental abnormalities of the
craniofacial and musculoskeletal systems, pregnancy termination and
stillbirth.
Reproductive Effects:
see above.
Neurotoxicity:
No data available.
Mutagenicity:
No data available.
Other Studies:
No data available.