Gilles Berger
MIT - Department of Chemistry

Ph.D., Pharm.D.




[1] G. Berger, R. Gasper, D. Lamoral-Theys, A. Wellner, M. Gelbcke, R. Gust, J. Nève, E. Goormaghtigh, R. Kiss, F. Dufrasne, Fourier transform infrared spectroscopy to monitor the cellular impact of newly synthesized platinum derivatives, International Journal of Oncology 37 (2010) 679-686.

[2] G. Berger, M. Gelbcke, E. Cauët, M. Luhmer, J. Nève, F. Dufrasne, Synthesis of 15N-labeled vicinal diamines through N-activated chiral aziridines: tools for the NMR study of platinum-based anticancer compounds, Tetrahedron Letters 54 (2013) 545-548.

[3] G. Berger, Using conceptual DFT to rationalize regioselectivity: a case study on the nucleophilic ring-opening of activated aziridines, Computational and Theoretical Chemistry 1010 (2013) 11-18.

[4] G. Berger, J. Soubhye, A. Van Der Lee, R. Wintjens, P. Dubois, S. Clément, F. Meyer, Interplay between halogen bonding and lone pair-π interactions: A computational and crystal packing study, ChemPlusChem 79 (2014) 552-55.

[5] G. Berger, H. Leclercqz, A. Derenne, M. Gelbcke, E. Goormaghtigh, J. Nève, V. Mathieu, F. Dufrasne, Synthesis and in vitro characterization of platinum(II) anticancer coordinates using FTIR spectroscopy and NCI Compare: a fast method for new compounds discovery, Bioorganic and Medicinal Chemistry 22 (2014) 3527-3536.

[6] G. Berger, L. Fusaro, M. Luhmer, B. Crousse, A. Van der Lee, F. Meyer, Synthesis of α-CF3 azanorbornene and azetidines by aza Diels-Alder and iodine-mediated cyclizations: application in ROMP and ligand design, Tetrahedron Letters 55 (2014) 6339-6342.

[7] G. Berger, J. Soubhye, F. Meyer, Halogen bonding in polymer science: from crystal engineering to functional supramolecular polymers and materials, Polym. Chem. 6 (2015) 3559-3580.

[8] G. Berger, L. Fusaro, M. Luhmer, J. Nève, F. Dufrasne, S. Bombard, Insight into the structure activity relationships of chiral 1,2-diaminophenylpropane platinum(II) anticancer derivatives, J. Biol. Inorg. Chem. 20 (2015) 841-853.

[9] G. Berger, R. Wintjens, F. Meyer, Preparation of racemic and optically active trifluoromethyl aziridines and azetidines, in: O.A. Attanasi, R. Noto, D. Spinelli (Eds.), Targets Heterocycl. Syst., Società Chimica Italiana, Roma, 2014: pp. 29-47.

[10] J. Sá, J. Czapla-Masztafiak, E. Lipiec, Y. Kayser, W. Kwiatek, B. Wood, G.B. Deacon, G. Berger, F. Dufrasne, D.L.A. Fernandes, J. Szlachetko The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules, Drug Discov. Today Technol. 16 (2015) 1-6.

[11] G. Berger, M. Vilchis-Reyes, S. Hanessian, Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano-L-Proline Oligomers: The Shortest Crystalline PPII-type Helical Proline-Derived Tetramer, Angew. Chemie Int. Ed. 54 (2015) 13268-13272.

[12] A.K. Chattopadhyay, V.L. Ly, J. Shashidhar, G. Berger, S. Hanessian Total synthesis of isodaphlongamine H : A possible biogenetic conundrum, Angew.Chem. Int.Ed. 55 (2016) 2577 –2581.

[13] G. Berger, K. Robijns, R. Wintjens, F. Meyer, Halogen bonding in multi-connected 1,2,2-triiodo-alkene involving geminal and/or vicinal iodines: A crystallographic and DFT study, CrystEngComm 18 (2016) 683–690.

[14] J. Sá, J. Czapla-Masztafiak, E. Lipiec, Y. Kayser, D.L.A. Fernandes, J. Szlachetko, F. Dufrasne, G. Berger, Resonant X-ray emission spectroscopy of platinum(II) anticancer complexes, Analyst 141 (2016) 1226-1232.

[15] A.K. Chattopadhyay, G. Berger, S. Hanessian, Strategies toward the total synthesis of calyciphylline B-type alkaloids: A computational perspective aided by DFT analysis, J. Org. Chem. 81 (2016) 5074−5086.

[16] I. Aldib, M. Gelbcke, J. Soubhye, M. Prévost, P.G. Furtmüller, C. Obinger, B. Elfving, I. Chikh Alard, G. Roos, C. Delporte, G. Berger, D. Dufour, K. Zouaoui Boudjeltia, J. Nève, F. Dufrasne, P. Van Antwerpen, Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study, Eur. J. Med. Chem. 123 (2016) 746–762.

[17] G. Berger, I. Chab-Majdalani, S. Hanessian, Properties of the amide bond involving 4,5-proline methanologues: an experimental and theoretical study, accepted for publication.

[18] V. Levet, R. Rosière, R. Merlos, L. Fusaro, G. Berger, K. Amighi, N. Wauthoz, Development of controlled-release cisplatin dry powder for inhalation, Int. J. Pharm. 515 (2016) 209-220.

[19] M. Marloye G. Berger, F. Dufrasne, A survey of the mechanisms of action of anticancer transition metal complexes, Future Med. Chem. 8 (2016) 2263-2286.

[20] Bin Chen, G. Berger, Stephen Hanessian, Bifunctional Cooperative Catalysis toward Tertiary β-Ketols, under review.



G. Berger et al. “Fourier Transform Infrared (FTIR) Spectroscopy to Monitor the Cellular Impact of Newly Synthesized Platinum Derivatives”, Oral presentation, PhD Day - Mons, May 2011.
“Synthesis and In Vitro Anticancer Properties of Platinum Derivatives”, Oral presentation, 15th Forum of Pharmaceutical Sciences - Spa, May 2011.         
G. Berger et al. “Synthesis and In Vitro Anticancer Properties of Platinum Derivatives”, Oral presentation, 25èmes Journées franco-belges de pharmacochimie - Liège, May 2011.
G. Berger et al. "Vicinal Diamines through N-Activated Chiral Aziridines: Synthesis and Conceptual Density Functional Theory Study”, Poster, 13th Belgian Organic Synthesis Symposium, BOSS - Leuven, July 2012
G. Berger et al. “Regioselective Opening of N-Activated Aziridines: A Quantum Chemical Study”, Poster, Journée Scientifique de la Société Royale de Chimie - Louvain-La-Neuve, October 2012.
G. Berger et al. “Chiral Diamines through the Regioselective Opening of Nitrogen-Activated Aziridines: Synthesis and Quantum Chemical Study”, Oral presentation, PhD Day - Bruxelles (ULB), October 2012
G. Berger et al. “Insight into the Structure-Activity Relationships of Platinum(II) Anticancer Coordinates”, Poster, PhD Day - Bruxelles (ULB), October 2012.
G. Berger et al. “Synthesis and in vitro characterization of anticancer platinum(II) coordinates: NCI Compare and FTIR spectroscopy for drug candidate profiling”, Poster, International Congress on BioInorganic Chemistry - Grenoble, July 2013.
G. Berger et al. "Synthesis of chiral vicinal diamines and in vitro anticancer properties of their platinum(II) coordinates", Oral presentation, Massachusetts Institute of Technology - Cambridge (under invitation from Prof. Stephen J. Lippard), November 2014.
G. Berger et al. "4,5-Methanoprolines, bifunctional-catalyzed aldol reactions and the chemistry of benzodiazidodiazines: from the bench to the theory", Oral presentation, Year-End Symposium (Hanessian Group), Université de Montréal - Montreal, November 2014.
G. Berger et al. "Strucural properties of 4,5-Methanoprolines and Their oligomers: An Unprecedented Crystalline PPII-Type Helical Tetramer", Oral presentation, 10th European Workshop on Drug Design - Siena, May 2015.
G. Berger et al. "Intramolecular Aldol Reactions toward Tertiary β-Ketols: A Theoretical Mechanistic Study", Poster, 10th European Workshop on Drug Design - Siena, May 2015.



G. Berger, "Synthesis of chiral vicinal diamines and in vitro anticancer properties of their platinum(II) coordinates" Advisor: Prof. François Dufrasne.

You will find a copy of my Ph.D. thesis here.