Summary

I.       The adaptive immune system: B cells, T cells- diverse, self-tolerant, and specific   

II.      Thymic Selection: positive and negative selection, specificity from weak amino-acids, extreme value distribution

III.     Quorum sensing for peripheral tolerance                                              

II.      Affinity Maturation: Evolution in the Germinal Center                             

dependence of potency on spike density   

         the puzzle of low HIV spike density                           

V.       Broadly neutralizing Antibodies: Sequential versus cocktail administration of antigen variants

vs.

VI.    Dynamics of HIV on a fitness landscape: Maximum entropy construction, mean-field approach

Physics Colloquium                                 Univerity of California, San Diego                         24 January 2019

Diversity, tolerance, and maturation of the adaptive immune response

Andrej Kosmrlj,     Hanrong Chen,       Assaf Amitai,         Shenshen Wang

Tom Butler, John Barton, A. Jha, E. Shakhnovich, E. Huseby

Arup K. Chakraborty 

Next (Adaptive immunity) Outline Adaptive Immunity Thymic Selection Quorum sensing Affinity Maturation Broadly neutralizing Abs EMF dynamics Summary