Summary

I.       Introduction: B cells, Antibodies and antigens                      

         the puzzle of low HIV spike density                           

II.      Affinity Maturation: Evolution in the Germinal Center 

III.      Fitness & Evolution: Competition for virus capture

dependence of potency on spike density   

IV.     Optimal density for synthetic nanoparticle vaccination; increased competition in HIV

A. Amitai, A.K. Chakraborty, M. Kardar PLOS Comp. Bio. doi.org/10.1371/journal.pcbi.1006408

V.       Broadly neutralizing Antibodies: Controlling affinity maturation against a mutable virus

vs.

VI.    Predicting evolution of viral sequences: Mean-field dynamics on a fitness landscape

Nordita program on         From Molecular Basis to Predictability and Control of Evolution        Stockholm, 24 July 2019

                Assaf Amitai            Shenshen Wang    Arup K. Chakraborty      

              Hanrong Chen     John Barton        Scott Shaffer       Penny Moore                          

Next (Introduction) Outline Introduction Affinity Maturation Fitness & Evolution Optimal density Broadly neutralizing Abs EMF dynamics Summary